ProcessCmdKey

 Public Class Form1

    Protected Overrides Function ProcessCmdKey(ByRef msg As Message, keyData As Keys) As Boolean

        Select Case keyData

            Case (Keys.F10 Or Keys.Shift Or Keys.Control)

                MessageBox.Show("You pressed Shft+Ctrl+F10.")

                Return True

            Case (Keys.F10 Or Keys.Control)

                MessageBox.Show("You pressed Ctrl+F10.")

                Return True

            Case Keys.F10

                MessageBox.Show("You pressed F10.")

                Return True

        End Select

        Return MyBase.ProcessCmdKey(msg, keyData)

    End Function

End Class

Option Strict On

Public Class Form1

    Private Sub Form1_Load(sender As Object, e As EventArgs) Handles MyBase.Load

        Me.Location = New Point(CInt((Screen.PrimaryScreen.WorkingArea.Width / 2) - (Me.Width / 2)), CInt((Screen.PrimaryScreen.WorkingArea.Height / 2) - (Me.Height / 2)))

        Me.KeyPreview = True

    End Sub

    Private Sub Form1_KeyDown(sender As Object, e As KeyEventArgs) Handles Me.KeyDown

        If e.KeyCode = Keys.F10 Then

            e.Handled = True

            Button2_Click(Me, Nothing)

        End If

        If e.Control AndAlso e.KeyCode = Keys.B Then

            e.Handled = True

            Button2_Click(Me, Nothing)

        End If

    End Sub

    Private Sub Button1_Click(sender As Object, e As EventArgs) Handles Button1.Click

        Button2.Text = ChrW(38) & "Follow"

    End Sub

    Private Sub Button2_Click(sender As Object, e As EventArgs) Handles Button2.Click

        MessageBox.Show("Button2 selected.")

    End Sub

End Class